Faculty Information |

SUGIMORI Hiroki Faculty of Sports and Health Science Department of Nursing Professor

■ Title
The levels of serum soluble CD86 are correlated with the expression of CD86 variant 3 gene and are prognostic indicators in patients with myeloma

■ Outline
  We previously showed that cell-surface CD86 expressed on multiple myeloma (MM) cells contributed to not only tumor growth but also antitumor cytotoxic T-lymphocyte responses mediated by induction of IL-10-producing CD4+ T cells. The soluble form of CD86 (sCD86) was also detected in serum from patients with MM. Thus, to determine whether sCD86 levels are a useful prognostic factor, we investigated the association of serum sCD86 levels with disease progression and prognosis in 103 newly diagnosed patients with MM. Serum sCD86 was detected in 71% of the patients with MM but was only rarely detected in patients with monoclonal gammopathy of undetermined significance and healthy controls, and the level was significantly increased in patients with advanced-stage MM. When we examined differences in clinical characteristics according to the level of serum sCD86, those in the high (>=2.18 ng/mL, n = 38) group exhibited more aggressive clinical characteristics, with shorter overall survival times compared with those in the low (<2.18 ng/mL, n = 65) group. On the other hand, it was difficult to stratify the patients with MM into different risk groups based on the expression levels of cell-surface CD86. The levels of serum sCD86 were significantly correlated with the expression levels of the messenger RNA (mRNA) transcripts of CD86 variant 3, which lack exon 6, resulting in a truncated transmembrane region, and its variant transcripts were upregulated in the high group. Thus, our findings suggest that sCD86 can be easily measured in peripheral blood samples and is a useful prognostic marker in patients with MM.
  Ryosuke Kinoshitaa, Mariko Ishibashib, Hiroshi Handac, Makoto Sasakid, Yoichi Imaie, Norina Tanakaf, Shigeki Itog, Mika Sunakawa-Kiia, Yuta Kaitoa, Toshio Asayamaa, Norio Komatsud, Junji Tanakaf,Takeshi Odajimah, Hiroki Sugimorii, Hiroki Yamaguchia, Koiti Inokuchia, and Hideto Tamuraa,j
  Collaboration   Experimental Hematology   Elsevior      2023/02